Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

@inproceedings{Tsaponina2013PreactivationOT,
  title={Pre-activation of the genome integrity checkpoint increases DNA damage tolerance},
  author={Olga Tsaponina and Andrei Chabes},
  booktitle={Nucleic acids research},
  year={2013}
}
The genome integrity checkpoint is a conserved signaling pathway that is regulated in yeast by the Mec1 (homologous to human ATR) and Rad53 (homologous to human Chk1) kinases. The pathway coordinates a multifaceted response that allows cells to cope with DNA damage and DNA replication stress. The full activation of the checkpoint blocks origin firing… CONTINUE READING