Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice.

@article{Yoon2015PreactivatedHM,
  title={Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice.},
  author={N. Yoon and M. S. Park and Grantham C. Peltier and R. H. Lee},
  journal={Cytotherapy},
  year={2015},
  volume={17 10},
  pages={
          1332-41
        }
}
BACKGROUND AIMS Previously, we showed that human mesenchymal stromal cells (hMSCs) were activated to express tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) upon TNF-α stimulation, induced cell death in triple-negative breast cancer (TNBC) MDA-MB-231 cells (MDA), and RNA released from apoptotic MDA further increased TRAIL expression in hMSCs. This feed-forward stimulation increased apoptosis in MDA cells. Here, we tested whether TRAIL-expressing hMSCs, in combination with… Expand
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β
Engineered Mesenchymal Stem Cells as an Anti-Cancer Trojan Horse.
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