Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy

@inproceedings{Crespo2015PreTransplantDT,
  title={Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy},
  author={Elena Crespo and Marc L{\'u}cia and Josep Mar{\'i}a Cruzado and Sergio Oscar Luque and Edoardo Melilli and Anna Manonelles and N{\'u}ria Lloberas and Juan Torras and Josep Mar{\'i}a Grinyo and Oriol Bestard},
  booktitle={PloS one},
  year={2015}
}
Preformed T-cell immune-sensitization should most likely impact allograft outcome during the initial period after kidney transplantation, since donor-specific memory T-cells may rapidly recognize alloantigens and activate the effector immune response, which leads to allograft rejection. However, the precise time-frame in which acute rejection is fundamentally triggered by preformed donor-specific memory T cells rather than by de novo activated naïve T cells is still to be established. Here… CONTINUE READING