Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria

@inproceedings{GingellLittlejohn2013PreTransplantCE,
  title={Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria},
  author={Marc Gingell-Littlejohn and Dagmara McGuinness and Liane Mcglynn and David Kingsmore and Karen S. Stevenson and Christian Koppelstaetter and Marc James Clancy and Paul G Shiels},
  booktitle={PloS one},
  year={2013}
}
CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post-transplant serum creatinine when compared to "Gold Standard" clinical factors, such as cold ischaemic time and donor chronological age. This report shows that CDKN2A is better than telomere length, the most celebrated biomarker of ageing, as a predictor of post-transplant renal… CONTINUE READING
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