Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.

@article{Talora2003PreTCRtriggeredES,
  title={Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.},
  author={Claudio Talora and Antonio Francesco Campese and Diana Bellavia and Monica Pascucci and Saula Checquolo and Manuela Groppioni and Luigi Frati and Harald von Boehmer and Alberto Gulino and Isabella Screpanti},
  journal={EMBO reports},
  year={2003},
  volume={4 11},
  pages={1067-72}
}
Notch and basic helix-loop-helix E2A pathways specify cell fate and regulate neoplastic transformation in a variety of cell types. Whereas Notch enhances tumorigenesis, E2A suppresses it. However, whether and how Notch and E2A interact functionally in an integrative mechanism for regulating neoplastic transformation remains to be understood. It has been shown that Notch3-induced T-cell leukaemia is abrogated by the inactivation of pTalpha/pre-T-cell antigen receptor (pre-TCR). We report here… CONTINUE READING
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