Pre-Existing Isoniazid Resistance, but Not the Genotype of Mycobacterium Tuberculosis Drives Rifampicin Resistance Codon Preference in Vitro

@inproceedings{Bergval2012PreExistingIR,
  title={Pre-Existing Isoniazid Resistance, but Not the Genotype of Mycobacterium Tuberculosis Drives Rifampicin Resistance Codon Preference in Vitro},
  author={Indra L. Bergval and Brian Kwok and Anja R. J. Schuitema and Kristin Kremer and Dick van Soolingen and Paul R. Klatser and Richard Anthony},
  booktitle={PloS one},
  year={2012}
}
Both the probability of a mutation occurring and the ability of the mutant to persist will influence the distribution of mutants that arise in a population. We studied the interaction of these factors for the in vitro selection of rifampicin (RIF)-resistant mutants of Mycobacterium tuberculosis. We characterised two series of spontaneous RIF-resistant in… CONTINUE READING