Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.

@article{Vosshenrich2004PreBCR,
  title={Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.},
  author={Christian A. J. Vosshenrich and Ana Cumano and Werner M{\"u}ller and James P Di Santo and Paulo Vieira},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 30},
  pages={11070-5}
}
IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse. On the one hand, TSLP is able to give rise to a measurable B1 cell compartment derived from fetal liver pro-B cells, although, as is the case for B2 cells, it does not play a… CONTINUE READING