Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.

@article{Corcos1995PreBcellDI,
  title={Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.},
  author={Daniel Corcos and Olga Dunda and C{\'e}cile Butor and Jean Yves Cesbron and Patrick Lor{\`e}s and Danielle Bucchini and Jacques Jami},
  journal={Current biology : CB},
  year={1995},
  volume={5 10},
  pages={1140-8}
}
BACKGROUND Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains. We have previously proposed--by analogy to the process by which mutated growth factor receptors can be oncogenic--that because the genetic defects in HCDs result in the production of abnormal membrane-associated heavy chains lacking an antigen-binding domain, these abnormal B-cell antigen receptors might engage… CONTINUE READING
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