Pre-ART Levels of Inflammation and Coagulation Markers Are Strong Predictors of Death in a South African Cohort with Advanced HIV Disease

@inproceedings{Ledwaba2012PreARTLO,
  title={Pre-ART Levels of Inflammation and Coagulation Markers Are Strong Predictors of Death in a South African Cohort with Advanced HIV Disease},
  author={Lotty Ledwaba and Jorge A. Tavel and Paul Khabo and Patrick Maja and Jing Qin and Phumele Sangweni and Xiao Liu and Dean A Follmann and Julia A. Metcalf and Susan Orsega and Beth R. Baseler and James D. Neaton and H. Clifford Lane},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and D-dimer predict mortality in HIV patients on antiretroviral therapy (ART) with relatively preserved CD4+ T cell counts. We hypothesized that elevated pre-ART levels of these markers among patients with advanced HIV would be associated with an increased risk of death following the initiation of ART. METHODS Pre-ART plasma from patients with advanced HIV in South Africa was used to measure hsCRP, IL-6… CONTINUE READING