Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae.

@article{Osheim2004Pre18SRR,
  title={Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae.},
  author={Yvonne N. Osheim and Sarah L. French and Kristin M Keck and Erica A. Champion and Krasimir Spasov and François Dragon and S J Baserga and A. L. Beyer},
  journal={Molecular cell},
  year={2004},
  volume={16 6},
  pages={943-54}
}
Recent studies have revealed multiple dynamic complexes that are precursors to eukaryotic ribosomes. EM visualization of nascent rRNA transcripts provides in vivo temporal and structural context for these events. In exponentially growing S. cerevisiae, pre-18S rRNA is dramatically compacted into a large particle (SSU processome) within seconds of completion of its transcription and is released cotranscriptionally by cleavage in ITS1. After cleavage, a new terminal knob is formed on the nascent… CONTINUE READING
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