Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release.

Abstract

The M-type K(+) current (M-current), encoded by Kv7.2/3 (KCNQ2/3) K(+) channels, plays a critical role in regulating neuronal excitability because it counteracts subthreshold depolarizations. Here we have characterized the functions of pre- and postsynaptic M-channels using a novel Kv7.2/3 channel opener, NH6, which we synthesized as a new derivative of N… (More)

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@article{Peretz2007PreAP, title={Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release.}, author={Asher Peretz and Anton Sheinin and Cuiyong Yue and Nurit Degani-Katzav and Gilad Gibor and Rachel Nachman and Anna Gopin and Eyal Tam and Doron Shabat and Yoel Yaari and Bernard Attali}, journal={Journal of neurophysiology}, year={2007}, volume={97 1}, pages={283-95} }