Prdm9 controls activation of mammalian recombination hotspots.

  title={Prdm9 controls activation of mammalian recombination hotspots.},
  author={Emil D. Parvanov and Petko M Petkov and Kenneth Paigen},
  volume={327 5967},
Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminated as candidates. The remaining gene, Prdm9, codes for a zinc finger containing histone H3K4 trimethylase… CONTINUE READING
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