Prdm9 Polymorphism Unveils Mouse Evolutionary Tracks

@inproceedings{Kono2014Prdm9PU,
  title={Prdm9 Polymorphism Unveils Mouse Evolutionary Tracks},
  author={Hiromitsu Kono and Masaru Tamura and Naoki Osada and Hitoshi Suzuki and Kuniya Abe and Kazuo Moriwaki and Kunihiro Ohta and Toshihiko Shiroishi},
  booktitle={DNA research : an international journal for rapid publication of reports on genes and genomes},
  year={2014}
}
PR/SET domain containing 9 (Prdm9) mediates histone modifications such as H3K4me3 and marks hotspots of meiotic recombination. In many mammalian species, the Prdm9 gene is highly polymorphic. Prdm9 polymorphism is assumed to play two critical roles in evolution: to diversify the spectrum of meiotic recombination hotspots and to cause male hybrid sterility, leading to reproductive isolation and speciation. Nevertheless, information about Prdm9 sequences in natural populations is very limited. In… CONTINUE READING
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