Prdm9 Incompatibility Controls Oligospermia and Delayed Fertility but No Selfish Transmission in Mouse Intersubspecific Hybrids

@inproceedings{Flachs2014Prdm9IC,
  title={Prdm9 Incompatibility Controls Oligospermia and Delayed Fertility but No Selfish Transmission in Mouse Intersubspecific Hybrids},
  author={Petr Flachs and Tanmoy 4 Bhattacharyya and Ondřej Mihola and Jaroslav Pi{\'a}lek and Jir{\'i} Forejt and Zdenek Trachtulec},
  booktitle={PloS one},
  year={2014}
}
PR-domain 9 (Prdm9) is the first hybrid sterility gene identified in mammals. The incompatibility between Prdm9 from Mus musculus domesticus (Mmd; the B6 strain) and the Hstx2 region of chromosome (Chr) X from M. m. musculus (Mmm; the PWD strain) participates in the complete meiotic arrest of mouse intersubspecific (PWD×B6)F1 hybrid males. Other studies suggest that also semisterile intersubspecific hybrids are relevant for mouse speciation, but the genes responsible remain unknown. To… CONTINUE READING