Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.

@article{Harms2014Prdm16IR,
  title={Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.},
  author={Matthew J. Harms and Jeff Ishibashi and Wenshan Wang and H. Lim and S. Goyama and T. Sato and M. Kurokawa and Kyoung-Jae Won and P. Seale},
  journal={Cell metabolism},
  year={2014},
  volume={19 4},
  pages={
          593-604
        }
}
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose tissue (BAT) in vivo has been unclear. By analyzing mice that selectively lacked Prdm16 in the brown adipose lineage, we found that Prdm16 was dispensable for embryonic BAT development. However, Prdm16 was required in young mice to suppress the expression of white-fat-selective genes in BAT… Expand
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