• DOI:10.1172/JCI44271
Corpus ID: 8863594

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

@article{Seale2011Prdm16DT,
  title={Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.},
  author={P. Seale and Heather M. Conroe and J. Estall and S. Kajimura and A. Frontini and Jeff Ishibashi and P. Cohen and S. Cinti and B. Spiegelman},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 1},
  pages={
          96-105
        }
}

• P. Seale, Heather M. Conroe, +6 authors B. Spiegelman
• Published 2011
• Biology, Medicine
• The Journal of clinical investigation

The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while expansion of subcutaneous fat does not carry the same risks. Brown adipose produces heat as a defense against hypothermia and obesity, and the appearance of brown-like adipocytes within white adipose tissue depots is associated with improved metabolic phenotypes. Thus, understanding the differences in… Expand

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