Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

  title={Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.},
  author={Patrick Seale and Heather M. Conroe and Jennifer L. Estall and Shingo Kajimura and Andrea Frontini and Jeff Ishibashi and Paul Cohen and Saverio Cinti and Bruce M. Spiegelman},
  journal={The Journal of clinical investigation},
  volume={121 1},
The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while expansion of subcutaneous fat does not carry the same risks. Brown adipose produces heat as a defense against hypothermia and obesity, and the appearance of brown-like adipocytes within white adipose tissue depots is associated with improved metabolic phenotypes. Thus, understanding the differences in… 

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