Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis

@article{Reist2020PrazosinFT,
  title={Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis},
  author={Christopher Reist and Elani Streja and Cynthia Crystal Tang and Bryan Shapiro and Jim Mintz and Michael Hollifield},
  journal={CNS Spectrums},
  year={2020},
  volume={26},
  pages={338 - 344}
}
Abstract Background Prazosin has been an accepted treatment for patients with post-traumatic stress disorder (PTSD) who experience sleep disturbances, including nightmares. Results of a recent large randomized control trial did not find benefit of prazosin vs placebo in improving such outcomes. A meta-analysis that includes this most recent trial was conducted to examine the pooled effect of prazosin vs placebo on sleep disturbances and overall PTSD symptoms in patients with PTSD. Methods A… 

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References

SHOWING 1-10 OF 44 REFERENCES

Efficacy of Prazosin in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis.

This study suggests that prazosin improves nightmares and overall PTSD symptoms including hyperarousal, sleep disturbances, total sleep time, and sleep quality.

Meta-analysis of the efficacy and safety of prazosin versus placebo for the treatment of nightmares and sleep disturbances in adults with posttraumatic stress disorder

PTSD-related nightmares, sleep disturbances, and overall illness severity showed a significant response to treatment with prazosin, with careful dose titration.

Trial of Prazosin for Post‐Traumatic Stress Disorder in Military Veterans

Prazosin did not alleviate distressing dreams or improve sleep quality in military veterans who had chronic PTSD, and there were no significant differences in these measures at 26 weeks of the trial.

Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.

These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms.

Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD).

  • J. IpserDan J Stein
  • Psychology, Medicine
    The international journal of neuropsychopharmacology
  • 2012
The largest body of evidence for short- and long-term efficacy of medication currently exists for SSRIs, with promising initial findings for the selective noradrenergic reuptake inhibitor venlafaxine and the atypical antipsychotic risperidone.

Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting.

Sertraline was not demonstrated to be efficacious in the treatment of PTSD in the VA clinic settings studied, and gender, duration of illness, severity of injury, type of trauma, and history of alcohol/substance abuse were explored as potential moderators of outcome, but no consistent effects were uncovered.