Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats

@article{Manion2007PrazosinAP,
  title={Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats},
  author={Sean Thomas Manion and Eleanore H Gamble and He Li},
  journal={Pharmacology Biochemistry and Behavior},
  year={2007},
  volume={86},
  pages={559-565}
}
Exposure to traumatic stress can result in a number of pathophysiological conditions, including post-traumatic stress disorder (PTSD). PTSD is characterized by a number of persistently heightened physiological and behavioral indicators, including increased sensory arousal and increased startle response. Similar effects can be seen in an animal model of PTSD in which stress results from restraint and inescapable tailshocks to rats. The present study used this animal model to investigate the… CONTINUE READING

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