Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.

@article{Pereira2021PraziquantelPR,
  title={Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.},
  author={Thiago de Almeida Pereira and Guilherme Vaz de Melo Trindade and Elisangela Trindade Santos and Fausto E.L. Pereira and M{\'a}rcia Maria de Souza},
  journal={International journal for parasitology},
  year={2021}
}
The pathogenesis of schistosomiasis and the mechanism of disease regression after Praziquantel pharmacotherapy are not fully elucidated. Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), and systemic OPN levels strongly correlate with disease severity, suggesting its use as a potential morbidity biomarker. In this study, we investigated the impact of Praziquantel use on systemic OPN levels and on liver collagen deposition in… Expand

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