Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.

  title={Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.},
  author={Thiago Almeida Pereira and Guilherme Vaz de Melo Trindade and Elisangela Trindade Santos and Fausto Edmundo Lima Pereira and M{\'a}rcia Maria de Souza},
  journal={International journal for parasitology},
1 Citations

MicroRNA-181b promotes Schistosomiasis-induced Hepatic Fibrosis by targeting Smad7.



Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni

Circulating OPN levels are upregulated in human and murine acute schistosomiasis and could be a non-invasive biomarker of this form of disease.

The combined treatment of praziquantel with osteopontin immunoneutralization reduces liver damage in Schistosoma japonicum-infected mice

It is believed that the combined regimen of osteopontin immunoneutralization and anti-helminthic treatment can reduce the granulomatous response and liver fibrosis during the schistosomal hepatopathologic course.

Schistosomiasis and liver fibrosis

  • Z. Andrade
  • Medicine, Biology
    Parasite immunology
  • 2009
Host–parasite interactions in schistosomiasis help to understand a number of important features of liver fibrosis: its initiation and regulation, the significance of accompanying vascular changes, the dynamics of fibrosis formation and regression with antiparasitic treatment; host genetic and immunological contributions, and the pathophysiology of portal hypertension.

Osteopontin: Versatile modulator of liver diseases

  • S. Nagoshi
  • Medicine, Biology
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2014
The single nucleotide polymorphism in the promoter region of the OPN gene was shown to be associated with activity of hepatitis in chronic hepatitis C patients, prognosis in patients with HCC, and growth and lung metastasis of HCC xenografts in nude mice.

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools.

  • J. Lambertucci
  • Medicine
    Revista da Sociedade Brasileira de Medicina Tropical
  • 2014
Different aspects of hepatosplenic schistosomiasis are revisited here and the combination of a comprehensive history and physical examination, basic laboratory tests, biomarkers for liver fibrosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease.

Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis.

Hepatosplenic schistosomiasis was the first human disease in which the possibility of extensive long standing hepatic fibrosis being degraded and removed has been demonstrated and the main signs of portal hypertension progressively disappeared, implying that a profound vascular remodeling was concomitantly occurring.


Schistosomiasis elimination will require a multifaceted approach, including: treatment; snail control; information, education and communication; improved water, sanitation and hygiene; accurate diagnostics; and surveillance-response systems that are readily tailored to social-ecological settings.