Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.

  title={Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.},
  author={Thiago de Almeida Pereira and Guilherme Vaz de Melo Trindade and Elisangela Trindade Santos and Fausto E.L. Pereira and M{\'a}rcia Maria de Souza},
  journal={International journal for parasitology},
The pathogenesis of schistosomiasis and the mechanism of disease regression after Praziquantel pharmacotherapy are not fully elucidated. Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), and systemic OPN levels strongly correlate with disease severity, suggesting its use as a potential morbidity biomarker. In this study, we investigated the impact of Praziquantel use on systemic OPN levels and on liver collagen deposition in… Expand


Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
It is demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Expand
Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni
Circulating OPN levels are upregulated in human and murine acute schistosomiasis and could be a non-invasive biomarker of this form of disease. Expand
The combined treatment of praziquantel with osteopontin immunoneutralization reduces liver damage in Schistosoma japonicum-infected mice
It is believed that the combined regimen of osteopontin immunoneutralization and anti-helminthic treatment can reduce the granulomatous response and liver fibrosis during the schistosomal hepatopathologic course. Expand
Schistosomiasis and hepatic fibrosis regression.
A brief review of the studies directly related to schistosomiasis related to fibrosis formation and degradation is presented here to stress the progress obtained, and to point out to the need of further research. Expand
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. TheExpand
Schistosomiasis and liver fibrosis
  • Z. Andrade
  • Medicine, Biology
  • Parasite immunology
  • 2009
Host–parasite interactions in schistosomiasis help to understand a number of important features of liver fibrosis: its initiation and regulation, the significance of accompanying vascular changes, the dynamics of fibrosis formation and regression with antiparasitic treatment; host genetic and immunological contributions, and the pathophysiology of portal hypertension. Expand
Osteopontin: Versatile modulator of liver diseases
  • S. Nagoshi
  • Biology, Medicine
  • Hepatology research : the official journal of the Japan Society of Hepatology
  • 2014
The single nucleotide polymorphism in the promoter region of the OPN gene was shown to be associated with activity of hepatitis in chronic hepatitis C patients, prognosis in patients with HCC, and growth and lung metastasis of HCC xenografts in nude mice. Expand
Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools.
  • J. Lambertucci
  • Medicine
  • Revista da Sociedade Brasileira de Medicina Tropical
  • 2014
Different aspects of hepatosplenic schistosomiasis are revisited here and the combination of a comprehensive history and physical examination, basic laboratory tests, biomarkers for liver fibrosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. Expand
Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis.
Hepatosplenic schistosomiasis was the first human disease in which the possibility of extensive long standing hepatic fibrosis being degraded and removed has been demonstrated and the main signs of portal hypertension progressively disappeared, implying that a profound vascular remodeling was concomitantly occurring. Expand
Osteopontin - A potential biomarker of advanced liver disease.
The targeting of OPN pathways seems to be a promising approach in the treatment of chronic liver diseases, due to its versatile signaling functions. Expand