Praziquantel impairs the ability of exogenous serotonin to stimulate carbohydrate metabolism in intact Schistosoma mansoni

@article{Harder1987PraziquantelIT,
  title={Praziquantel impairs the ability of exogenous serotonin to stimulate carbohydrate metabolism in intact Schistosoma mansoni},
  author={Achim Harder and J. J. Abbink and Peter Andrews and Helmut Thomas},
  journal={Parasitology Research},
  year={1987},
  volume={73},
  pages={442-445}
}
Praziquantel (PZQ) (Droncit, Biltricide) at 10 ΜM completely abolishes the stimulatory effect of serotonin on glucose uptake and lactate excretion of Schistosoma mansoni. Fluoxetine (FXT) exerts similar effects on the serotonin-induced stimulation of glucose uptake and lactate excretion, however, at 100-fold higher concentrations. In comparison with PZQ, which is inhibitory at 10 ΜM, FXT and other amphiphilic cationic drugs (amitriptyline, propranolol, imipramine, chlorpromazine) inhibit… CONTINUE READING
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