Praziquantel: physiological evidence for its site(s) of action in magnesium-paralysed Schistosoma mansoni.

@article{Blair1992PraziquantelPE,
  title={Praziquantel: physiological evidence for its site(s) of action in magnesium-paralysed Schistosoma mansoni.},
  author={Kevin L Blair and James L. Bennett and Ralph A. Pax},
  journal={Parasitology},
  year={1992},
  volume={104 Pt 1},
  pages={
          59-66
        }
}
The mechanism whereby praziquantel produces a contraction and subsequent flaccid paralysis (a loss of sensitivity to subsequent stimuli) of Schistosoma mansoni in a medium containing an elevated Mg2+:Ca2+ ratio was investigated. In RPMI, praziquantel produced a concentration-dependent tonic contraction of the parasite with an EC50 of 200 nM. Magnesium inhibited the contraction in such a manner as to convert the tonic contraction to a phasic one without altering the peak force generated. The Mg… Expand
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
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TLDR
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