Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model.

  title={Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model.},
  author={Keiichi Kumasawa and Masahito Ikawa and Hiroyasu Kidoya and Hidetoshi Hasuwa and Tomoko Saito-Fujita and Yuka Morioka and Nobuyuki Takakura and Tadashi Kimura and Masaru Okabe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 4},
Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in preeclampsia using a lentiviral vector-mediated placenta-specific expression system… CONTINUE READING
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