Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

@article{Tsur2019PravastatinIF,
  title={Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.},
  author={Abraham Tsur and Flora S. Kalish and Jordan Burgess and Nihar Ranjan Nayak and Hui Zhao and Kerriann M Casey and Maurice L. Druzin and Ronald J Wong and David K. Stevenson},
  journal={Placenta},
  year={2019},
  volume={75},
  pages={
          1-8
        }
}
INTRODUCTION Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a partial HO-1 deficiency. METHODS At E14.5, untreated pregnant wild-type (WT, n=13-18), untreated HO-1+/- (Het, n=6-9), and Het mice treated with pravastatin (Het+Pravastatin, n… CONTINUE READING
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