Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis

@article{Cheng2008PravastatinAC,
  title={Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis},
  author={C. Cheng and S C Juan and J Chen and Ying-Chi Chao and His-Hsien Chen and Wei-Shiung Lian and Chun-Yi Lu and C. H. J. Chang and Ted-H Chiu and Heng Lin},
  journal={Apoptosis},
  year={2008},
  volume={13},
  pages={883-894}
}
The objective of this study was to evaluate the cardiac toxicity induced by carboplatin, a second generation platinum-containing anti-cancer drug, and to test whether pravastatin can reduce this cardio-toxicity. In the present study, infusion of carboplatin (100 mg/kg) to mice resulted in decreased survival rates and abnormal cardiac histology, concomitant with increased cardiac apoptosis. In addition, treatment of cultured rat cardiomyocytes with carboplatin (100 μM for 48 h) caused marked… CONTINUE READING

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