Pramipexole inhibits MPTP toxicity in mice by dopamine D3 receptor dependent and independent mechanisms.

@article{Ramirez2003PramipexoleIM,
  title={Pramipexole inhibits MPTP toxicity in mice by dopamine D3 receptor dependent and independent mechanisms.},
  author={Andres D Ramirez and Stephen K-F Wong and Frank S. Menniti},
  journal={European journal of pharmacology},
  year={2003},
  volume={475 1-3},
  pages={29-35}
}
The role of dopamine D3 receptors was investigated in mediating the neuroprotective effect of the dopamine D2/D3 receptor agonist (S)-2-amino-4,5,6,7-tetrahydro-6-propylamine-benzothiazole (pramipexole) in vivo. Pramipexole retained the ability to inhibit 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine depletion in mice in which the dopamine D3 receptor had been deleted. However, the neuroprotective efficacy was reduced in the dopamine D3 receptor-deleted mice compared to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…