Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial

@article{Barone2010PramipexoleFT,
  title={Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial},
  author={Paolo Barone and Werner Poewe and Stefan Tobias Albrecht and Catherine Debieuvre and D. D. Massey and Olivier Rascol and Eduardo Tolosa and Daniel J. Weintraub},
  journal={The Lancet Neurology},
  year={2010},
  volume={9},
  pages={573-580}
}
BACKGROUND Depression is common in patients with Parkinson's disease, but evidence on the efficacy of antidepressants in this population is lacking. Because depression in patients with Parkinson's disease might be related to dopaminergic dysfunction, we aimed to assess the efficacy of the dopamine agonist pramipexole for treatment of depressive symptoms in patients with Parkinson's disease. METHODS We did a 12-week randomised, double-blind, placebo-controlled (1:1 ratio) trial of pramipexole… CONTINUE READING
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