Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity

@article{Godwin2003PragmaticCC,
  title={Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity},
  author={Marshall Godwin and Lucia Ruhland and Ian Casson and Susan E MacDonald and Dianne Delva and Richard V Birtwhistle and Miu Lam and Rachelle M Seguin},
  journal={BMC Medical Research Methodology},
  year={2003},
  volume={3},
  pages={28 - 28}
}
BACKGROUND Controlled clinical trials of health care interventions are either explanatory or pragmatic. Explanatory trials test whether an intervention is efficacious; that is, whether it can have a beneficial effect in an ideal situation. Pragmatic trials measure effectiveness; they measure the degree of beneficial effect in real clinical practice. In pragmatic trials, a balance between external validity (generalizability of the results) and internal validity (reliability or accuracy of the… CONTINUE READING
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