Practice-Based Evidence Study Design for Comparative Effectiveness Research
@article{Horn2007PracticeBasedES, title={Practice-Based Evidence Study Design for Comparative Effectiveness Research}, author={Susan D. Horn and Julie Gassaway}, journal={Medical Care}, year={2007}, volume={45}, pages={S50-S57} }
Objectives:To describe a new, rigorous, comprehensive practice-based evidence for clinical practice improvement (PBE-CPI) study methodology, and compare its features, advantages, and disadvantages to those of randomized controlled trials and sophisticated statistical methods for comparative effectiveness research. Research Design:PBE-CPI incorporates natural variation within data from routine clinical practice to determine what works, for whom, when, and at what cost. It uses the knowledge of…
251 Citations
Practice Based Evidence: Incorporating Clinical Heterogeneity and Patient-Reported Outcomes for Comparative Effectiveness Research
- Medicine, PsychologyMedical care
- 2010
Practice-based evidence studies are an alternative to randomized controlled trials, well suited to determine what works best for specific patient types, and provide clinicians with a rational basis for treatment recommendations for individual patients.
Practice-based evidence research in rehabilitation: an alternative to randomized controlled trials and traditional observational studies.
- Medicine, PsychologyArchives of physical medicine and rehabilitation
- 2012
An Introduction to Comparative Effectiveness Research
- MedicineNeurosurgery
- 2012
This research paradigm strengthens the final step in clinical research that should follow the traditional demonstration of efficacy and reemphasizes the potentially important role of observational and retrospective investigations in establishing effectiveness of efficacious procedures in actual application to individual patients.
Practice-Based Evidence in Community Guide Systematic Reviews
- Medicine, Political ScienceAmerican journal of public health
- 2017
The inclusion of substantial PBE in Community Guide reviews suggests that evidence of adequate rigor to inform practice is being produced, and should increase stakeholders' confidence that The Community Guide provides recommendations with real-world relevance.
The Use of Patient-reported Outcomes (PRO) Within Comparative Effectiveness Research: Implications for Clinical Practice and Health Care Policy
- Medicine, Political ScienceMedical care
- 2012
The recommendations presented for incorporating PROs in CER are intended to provide a guide to researchers, clinicians, and policy makers to ensure that information derived from PROs is applicable and interpretable for a given CER context.
Interrupted Time Series Design: A Useful Approach for Studying Interventions Targeting Participation
- PsychologyPhysical & occupational therapy in pediatrics
- 2014
This work proposes the use of interrupted time series (ITS) quasi-experimental design for its potential application in determining the effectiveness of participation-focused interventions, ascertaining its advantages and limitations.
Emerging Methods in Comparative Effectiveness and Safety: Symposium Overview and Summary
- MedicineMedical care
- 2007
Conference papers covered numerous points about ways to structure both interventional and database-oriented studies, particularly those concerned with adverse drug events, to avoid bias in those studies, and to apply advanced statistical tools to exploit the information from these studies to their fullest.
Comparative effectiveness and implementation research: Directions for Neurology
- MedicineAnnals of neurology
- 2012
Neuroscientists and neuroscientists should understand the scope and objectives of comparative effectiveness and implementation research, their range of methodological approaches, and existing research resources relevant to research for neurological conditions, to close the well‐documented evidence‐to‐practice gap.
Practice based research in dentistry: an alternative to deal with clinical questions.
- Medicine, PsychologyBrazilian oral research
- 2020
This review sought to present PBR studies as alternative designs to answer clinical questions, but not replacing randomized clinical trials.
A Tipping Point for Measurement-Based Care.
- Medicine, PsychologyPsychiatric services
- 2017
OBJECTIVE
Measurement-based care involves the systematic administration of symptom rating scales and use of the results to drive clinical decision making at the level of the individual patient. This…
References
SHOWING 1-10 OF 39 REFERENCES
Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy.
- Medicine, Political ScienceJAMA
- 2003
Increasing the supply of pragmatic or practical clinical trials will depend on the development of a mechanism to establish priorities for these studies, significant expansion of an infrastructure to conduct clinical research within the health care delivery system, more reliance on high-quality evidence by health care decision makers, and a substantial increase in public and private funding forThese studies.
Practice-Based Research
- MedicineSocial work in health care
- 2007
This paper defines practice evaluation research, identifies strategies for its implementation, and describes a framework for creating a “research friendly” culture; it further describes the implementation of such an innovative program in both a hospital and a mental health agency setting.
Results of a collaborative quality improvement program on outcomes and costs in a tertiary critical care unit.
- MedicineCritical care medicine
- 1999
A focused quality improvement program in the ICU can have a beneficial impact on care and simultaneously reduce costs.
Formulary limitations and the elderly: results from the Managed Care Outcomes Project.
- Medicine, Political ScienceThe American journal of managed care
- 1998
Positive, significant associations were found between the independent variable formulary limitations in drug class and the dependent variables measuring resource utilization, sometimes significantly greater for elderly patients after controlling for severity of illness and other variables.
Applying the clinical practice improvement approach to stroke rehabilitation: methods used and baseline results.
- Medicine, PsychologyArchives of physical medicine and rehabilitation
- 2005
Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches.
- PsychologyAnnual review of public health
- 2000
An approach to making inferences about the causal effects of treatments or agents via potential outcomes is reviewed, where the causal effect is defined as a comparison of results from two or more alternative treatments, with only one of the results actually observed.
Treatment of Depression in Older Primary Care Patients in Health Maintenance Organizations
- Medicine, PsychologyInternational journal of psychiatry in medicine
- 1997
Psychotropic medication management is an important target for improving quality of care for older patients with depression in HMOs and decreasing inefficient minor tranquilizer use and increasing use of newer antidepressant medications may lead to improved outcomes for older depressed adults.
Newness of Drugs and Use of HMO Services by Asthma Patients
- Medicine, Political ScienceThe Annals of pharmacotherapy
- 2001
Greater use of newer asthma drugs was associated with significantly lower drug costs and fewer PCP visits; associations with hospitalization rates and ED visits, although lower, were not significant.
Development of a pediatric age- and disease-specific severity measure.
- MedicineThe Journal of pediatrics
- 2002
The age- and disease-specific pediatric CSI score correlates highly with LOS, cost, and mortality in hospitalized children and can help determine the best clinical practices for specific diseases and adjust for differences in severity of illness across providers.
Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness.
- MedicinePediatrics
- 2001
Institutional differences in care practices for children with VLRI were not explained by differences in patient severity and did not affect the children's recovery but correlated significantly with hospital costs and LOS.