Practice-Based Evidence Study Design for Comparative Effectiveness Research

@article{Horn2007PracticeBasedES,
  title={Practice-Based Evidence Study Design for Comparative Effectiveness Research},
  author={Susan D. Horn and Julie Gassaway},
  journal={Medical Care},
  year={2007},
  volume={45},
  pages={S50-S57}
}
Objectives:To describe a new, rigorous, comprehensive practice-based evidence for clinical practice improvement (PBE-CPI) study methodology, and compare its features, advantages, and disadvantages to those of randomized controlled trials and sophisticated statistical methods for comparative effectiveness research. Research Design:PBE-CPI incorporates natural variation within data from routine clinical practice to determine what works, for whom, when, and at what cost. It uses the knowledge of… 
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251 Citations
Highly Influential Citations
10
Background Citations
78
Methods Citations
28
Results Citations
3

251 Citations

Citation Type

Citation Type

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TLDR
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Practice-based evidence research in rehabilitation: an alternative to randomized controlled trials and traditional observational studies.
An Introduction to Comparative Effectiveness Research
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This research paradigm strengthens the final step in clinical research that should follow the traditional demonstration of efficacy and reemphasizes the potentially important role of observational and retrospective investigations in establishing effectiveness of efficacious procedures in actual application to individual patients.
Practice-Based Evidence in Community Guide Systematic Reviews
TLDR
The inclusion of substantial PBE in Community Guide reviews suggests that evidence of adequate rigor to inform practice is being produced, and should increase stakeholders' confidence that The Community Guide provides recommendations with real-world relevance.
The Use of Patient-reported Outcomes (PRO) Within Comparative Effectiveness Research: Implications for Clinical Practice and Health Care Policy
TLDR
The recommendations presented for incorporating PROs in CER are intended to provide a guide to researchers, clinicians, and policy makers to ensure that information derived from PROs is applicable and interpretable for a given CER context.
Interrupted Time Series Design: A Useful Approach for Studying Interventions Targeting Participation
TLDR
This work proposes the use of interrupted time series (ITS) quasi-experimental design for its potential application in determining the effectiveness of participation-focused interventions, ascertaining its advantages and limitations.
Emerging Methods in Comparative Effectiveness and Safety: Symposium Overview and Summary
TLDR
Conference papers covered numerous points about ways to structure both interventional and database-oriented studies, particularly those concerned with adverse drug events, to avoid bias in those studies, and to apply advanced statistical tools to exploit the information from these studies to their fullest.
Comparative effectiveness and implementation research: Directions for Neurology
TLDR
Neuroscientists and neuroscientists should understand the scope and objectives of comparative effectiveness and implementation research, their range of methodological approaches, and existing research resources relevant to research for neurological conditions, to close the well‐documented evidence‐to‐practice gap.
Practice based research in dentistry: an alternative to deal with clinical questions.
TLDR
This review sought to present PBR studies as alternative designs to answer clinical questions, but not replacing randomized clinical trials.
A Tipping Point for Measurement-Based Care.
OBJECTIVE Measurement-based care involves the systematic administration of symptom rating scales and use of the results to drive clinical decision making at the level of the individual patient. This…
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