Practical value of identifying antibodies to cryptic HLA epitopes in cardiac transplantation.

@article{Oaks2014PracticalVO,
  title={Practical value of identifying antibodies to cryptic HLA epitopes in cardiac transplantation.},
  author={Martin K. Oaks and Karen M. Michel and Nasir Z. Sulemanjee and Vinay Thohan and Francis X. Downey},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2014},
  volume={33 7},
  pages={713-20}
}
BACKGROUND Identification of antibodies to human leukocyte antigens (HLA) by single antigen bead arrays has led to the common practice of virtual crossmatching. However, inappropriate assignment of anti-HLA specificities can lead to false-positive virtual crossmatching, resulting in the decline of potentially crossmatch-negative organ offers. In this study we describe identification of antibodies to cryptic HLA present on denatured forms of HLA on single antigen bead array and provide a… CONTINUE READING
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