Practical value of genotypic analysis for diagnosing lymphoproliferative disorders.

@article{OConnor1987PracticalVO,
  title={Practical value of genotypic analysis for diagnosing lymphoproliferative disorders.},
  author={Nigel T.J. O'Connor and Kevin C. Gatter and J. S. Wainscoat and Joyce Crick and DavidB. Jones and Georges Delsol and Elisabeth Methner Ralfkiaer and Chris de Wolf-Peeters and Brian J. Angus and David Y. Mason},
  journal={Journal of clinical pathology},
  year={1987},
  volume={40 2},
  pages={
          147-50
        }
}
The value of DNA hybridisation (using immunoglobulin and T cell receptor gene probes) was assessed during the diagnosis of problematical lymphoid tissue biopsy specimens. In 14 of 18 specimens (78%), which contained a malignant lymphoproliferation of uncertain aetiology, this technique permitted the demonstration of a monoclonal proliferation of B cells (nine cases) or T cells (five cases). In five further lymph node biopsy specimens, in which the differential diagnosis lay between a reactive… CONTINUE READING

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