Practical side of multistage clinical trials for screening new agents.

  • Jay Herson
  • Published 1983 in Cancer treatment reports


Coordinating center operations are recommended for carrying out multistage phase II clinical trials in oncology. The relevant statistical issues in designing phase II trials are summarized. The predictive probability approach to multistage design is briefly described, along with an interactive computer program that facilitates design selection. A multistage… (More)


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