Practical model-based dose-finding in phase I clinical trials: methods based on toxicity.

@article{Thall2003PracticalMD,
  title={Practical model-based dose-finding in phase I clinical trials: methods based on toxicity.},
  author={Peter F. Thall and S H Lee},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2003},
  volume={13 3},
  pages={251-61}
}
We describe two practical, outcome-adaptive statistical methods for dose-finding in phase I clinical trials. One is the continual reassessment method and the other is based on a logistic regression model. Both methods use Bayesian probability models as a basis for learning from the accruing data during the trial, choosing doses for successive patient cohorts, and selecting a maximum tolerable dose (MTD). These methods are illustrated and compared to the conventional 3+3 algorithm by application… CONTINUE READING