Practical limits on the maximal speed of solution exchange for patch clamp experiments.

Abstract

Studying ligand-gated ion channels often requires the ability to change solutions quickly. Using finite element models, I have examined the practical limitations of how fast solutions can be exchanged on an outside-out patch using a dual stream switcher. The primary factors controlling the speed of response are the flow velocity, proximity of the patch to… (More)

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Cite this paper

@article{Sachs1999PracticalLO, title={Practical limits on the maximal speed of solution exchange for patch clamp experiments.}, author={Frederick Sachs}, journal={Biophysical journal}, year={1999}, volume={77 2}, pages={682-90} }