Practical limits of function prediction.

  title={Practical limits of function prediction.},
  author={Damien Devos and Alfonso Valencia},
  volume={41 1},
The widening gap between known protein sequences and their functions has led to the practice of assigning a potential function to a protein on the basis of sequence similarity to proteins whose function has been experimentally investigated. We present here a critical view of the theoretical and practical bases for this approach. The results obtained by analyzing a significant number of true sequence similarities, derived directly from structural alignments, point to the complexity of function… CONTINUE READING
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