Practical large scale synthesis of half-esters of malonic acid.

@article{Niwayama2009PracticalLS,
  title={Practical large scale synthesis of half-esters of malonic acid.},
  author={S. Niwayama and Hanjoung Cho},
  journal={Chemical \& pharmaceutical bulletin},
  year={2009},
  volume={57 5},
  pages={
          508-10
        }
}
A practical large-scale synthesis of monomethyl malonate and monoethyl malonate, which are among the most commonly applied half-esters in organic synthesis, is described, applying the highly efficient selective monohydrolysis of symmetric diesters we reported before. The optimal conditions with regard to the type of base, equivalent, co-solvents, and the reaction time have been examined for large-scale reactions. Monomethyl malonate and monoethyl malonate were obtained in high yields with near… Expand
Non-Enzymatic Desymmetrization Reactions in Aqueous Media
Water-mediated Desymmetrization Reactions
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