Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients

  title={Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients},
  author={Tiene Bauters and Patricia Rayner and Roxane Therrien and Sophie Van Lancker and Victoria Bordon and Marion Le Cordroch and Catharina Dhooge and Yves Beno{\^i}t and Johan Vandenbroucke},
  journal={Journal of Oncology Pharmacy Practice},
  pages={478 - 480}
Graft-versus-host-disease (GvHD) is the most frequent and important complication after allogeneic hematopoietic stem cell transplantation (HSCT). Despite aggressive immunosuppressive prophylaxis, GvHD can still occur even when the donor is a perfectly matched sibling. Prevention and treatment of GvHD remain a major challenge in allogeneic stem cell transplantation. Most centres use a combination of a calcineurin inhibitor (cyclosporine or tacrolimus) in conjunction with a short course… 
1 Citations
Role of the clinical pharmacist in a paediatric haemato-oncology stem cell transplantation ward
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Tacrolimus has been shown to be more effective than cyclosporine for prevention of acute graft-versus-host disease (GVHD) and was employed most frequently in combination with minimethotrexate (5 mg/m2 i.v).
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Long-term stability of a patient-convenient 1 mg/ml suspension of tacrolimus for accurate maintenance of stable therapeutic levels
These findings support new stability information of approximately 4 months for an extemporaneous oral suspension of tacrolimus at a concentration of 1 mg/ml, which is believed to be stable for use in pediatric patients.
Stability and sorption of FK 506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride, and polyolefin containers.
No substantial change in concentration occurred in FK 506 solution in 5% dextrose injection infused through PVC anesthesia extension tubing, PVC i.v. administration set tubing, or fat emulsion tubing, as well as the infused samples and samples collected from the containers and syringes.
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The Features Regarding the Absorption of Tacrolimus by PVC and PB Tubes and Effects of Such Absorption of Tacrolimus on the Blood Concentration and Dosage in Patients
It is shown that a large amount of tacrolimus was absorbed by the PVC tubes and that changes in the patients' blood concentrations were caused by the absorption of tacolimus by theVC tubes, and risk management is suggested.
Twice daily i.v. bolus tacrolimus infusion for GVHD prophylaxis in children undergoing stem cell transplantation
The results suggest that intermittent bolus i.v. tacrolimus administration is a safe and effective method of GVHD prophylaxis in children.