Practical considerations for using functional uniform prior distributions for dose-response estimation in clinical trials.

  • Björn Bornkamp
  • Published 2014 in Biometrical journal. Biometrische Zeitschrift

Abstract

Estimating nonlinear dose-response relationships in the context of pharmaceutical clinical trials is often a challenging problem. The data in these trials are typically variable and sparse, making this a hard inference problem, despite sometimes seemingly large sample sizes. Maximum likelihood estimates often fail to exist in these situations, while for… (More)
DOI: 10.1002/bimj.201300138

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