Practical considerations for the use of pseudorabies virus in transneuronal studies of neural circuitry.

@article{Card1998PracticalCF,
  title={Practical considerations for the use of pseudorabies virus in transneuronal studies of neural circuitry.},
  author={J. Patrick Card},
  journal={Neuroscience and biobehavioral reviews},
  year={1998},
  volume={22 6},
  pages={685-94}
}
The development of neurotrophic alpha herpesviruses for transneuronal analysis of neuronal circuitry has emerged from interdisciplinary characterizations of the viral life cycle and the defense response mounted by the nervous system to contain and eliminate the infection. Important findings from a number of fields have combined to provide compelling evidence that these viruses, when used appropriately, are powerful probes of multisynaptic circuits. These studies have also revealed that a number… CONTINUE READING