Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy.

@article{Tunis2003PracticalCT,
  title={Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy.},
  author={Sean R Tunis and Daniel B. Stryer and Carolyn M. Clancy},
  journal={JAMA},
  year={2003},
  volume={290 12},
  pages={
          1624-32
        }
}
Decision makers in health care are increasingly interested in using high-quality scientific evidence to support clinical and health policy choices; however, the quality of available scientific evidence is often found to be inadequate. Reliable evidence is essential to improve health care quality and to support efficient use of limited resources. The widespread gaps in evidence-based knowledge suggest that systematic flaws exist in the production of scientific evidence, in part because there is… 
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