Practical aspects of NMR-based fragment screening.


NMR spectroscopy is a popular and highly versatile screening method for fragment-based drug discovery. NMR methods are capable of robustly detecting the binding of fragments to macromolecular targets over an extraordinarily broad affinity range (from covalent to millimolar). This chapter provides a stepwise process for creating an NMR-based fragment… (More)
DOI: 10.1016/B978-0-12-381274-2.00009-1


Cite this paper

@article{Lepre2011PracticalAO, title={Practical aspects of NMR-based fragment screening.}, author={Christopher A Lepre}, journal={Methods in enzymology}, year={2011}, volume={493}, pages={219-39} }