Practical applications of chaos theory to the modulation of human ageing: nature prefers chaos to regularity

@article{Kyriazis2004PracticalAO,
  title={Practical applications of chaos theory to the modulation of human ageing: nature prefers chaos to regularity},
  author={Marios Kyriazis},
  journal={Biogerontology},
  year={2004},
  volume={4},
  pages={75-90}
}
From time to time, novel ways of interpreting and modifying ageing mechanisms are proposed. Occasionally, these lead to a conceptual dead end, whereas at other times new and vital insights into basic ageing mechanisms are gained. This review concentrates on one such way of interpreting and manipulating ageing processes, based on chaos (dynamical systems) theory. One prediction of this theory is that a wide-ranging loss of physiological complexity from molecular to cellular, and from tissue to… 

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References

SHOWING 1-10 OF 163 REFERENCES

Physiology and pathophysiology of senescence.

  • K. Schmidt
  • Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1999
TLDR
A brief review is presented on the different hypotheses aiming at explaining the physiology and pathophysiology of ageing and senescence.

[New horizons in medicine. Aging and the laws of modern physics].

  • G. Guarini
  • Physics
    Recenti progressi in medicina
  • 1994
TLDR
From the valuation of dynamic stability, dissipative structures and entropy, it appears possible in a near future to clarify many aspects of the nature and dynamics of aging.

Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence.

TLDR
If further research supports this hypothesis, measures of complexity based on chaos theory and the related geometric concept of fractals may provide new ways to monitor senescence and test the efficacy of specific interventions to modify the age-related decline in adaptive capacity.

Fractal dynamics in physiology: Alterations with disease and aging

TLDR
Application of fractal analysis may provide new approaches to assessing cardiac risk and forecasting sudden cardiac death, as well as to monitoring the aging process, and similar approaches show promise in assessing other regulatory systems, such as human gait control in health and disease.

Ageing and apoptosis

A system approach modelling of the three-stage non-linear kinetics in biological ageing

On possible role of chaotic behavior of the gene regulation system in aging

TLDR
This approach allows to hypothesize that at least at the level of gene regulation aging can be a chaotic process (here implied that chaos is a kind of the complex systems dynamics controlled by strictly determined rules).

Nonlinear Dynamics and Chaos Theory: Concepts and Applications Relevant to Pharmacodynamics

TLDR
Special attention is focused on three major fields of physiological systems with great importance in pharmacotherapy, namely cardiovascular, central nervous, and endocrine systems, where tools and concepts from nonlinear dynamics have been applied.

[On possible role of chaotic behavior of the gene regulation system in aging].

  • M. Soloviev
  • Biology
    Advances in gerontology = Uspekhi gerontologii
  • 2001
TLDR
This approach allows to hypothesize that at least at the level of gene regulation aging can be a chaotic process (here implied that chaos is a kind of the complex systems dynamics controlled by strictly determined rules).
...