Practical applications of chaos theory to the modulation of human ageing: nature prefers chaos to regularity

@article{Kyriazis2004PracticalAO,
  title={Practical applications of chaos theory to the modulation of human ageing: nature prefers chaos to regularity},
  author={Marios Kyriazis},
  journal={Biogerontology},
  year={2004},
  volume={4},
  pages={75-90}
}
  • M. Kyriazis
  • Published 2004
  • Medicine, Computer Science
  • Biogerontology
From time to time, novel ways of interpreting and modifying ageing mechanisms are proposed. Occasionally, these lead to a conceptual dead end, whereas at other times new and vital insights into basic ageing mechanisms are gained. This review concentrates on one such way of interpreting and manipulating ageing processes, based on chaos (dynamical systems) theory. One prediction of this theory is that a wide-ranging loss of physiological complexity from molecular to cellular, and from tissue to… Expand

Figures, Tables, and Topics from this paper

Nonlinear stimulation and hormesis in human aging: practical examples and action mechanisms.
TLDR
Novel types of innovative, mild, repeated stress or stimulation that challenge a biological system in a dose-response manner are likely to have an effect that, properly harnessed, can be used to delay, prevent, or reverse age-related changes in humans. Expand
Understanding and Modulating Ageing
TLDR
A combination of molecular, physiological and psychological modulatory approaches can realize “healthy ageing” as an achievable goal in the not‐so‐distant future. Expand
CHAOS THEORY: IMPACT ON AND APPLICATIONS IN MEDICINE
TLDR
This overview outlines a few salient areas in medicine that have successfully applied the principles of the chaos theory and their implications on the future course of medical diagnostics and health science systems as a whole. Expand
Deterministic Chaos and Fractal Complexity in the Dynamics of Cardiovascular Behavior: Perspectives on a New Frontier
  • Vijay Sharma
  • Biology, Medicine
  • The open cardiovascular medicine journal
  • 2009
TLDR
This review discusses the role of fractal structure and chaos in the cardiovascular system at the level of the heart and blood vessels, and at the cellular level and key functional consequences of these phenomena are highlighted. Expand
On the relationship between aging & cancer
TLDR
The cellular and molecular hallmarks of aging are identified and nine candidate hallmarks that are generally considered to contribute to the mammalian aging processes and together determine the aging phenotype are proposed. Expand
Clinical anti-aging hormetic strategies.
TLDR
The suggestion that mild stimulation or appropriately timed challenges may be used clinically in order to influence the impact of age-related disease and dysfunction is examined. Expand
Mechanisms underlying the age-related changes in muscle contractile properties
Changes in isometric fore and power output in old age have been extensively studied for but less attention has been paid to eccentric contractions where, paradoxically, there are suggestions thatExpand
Biological causes of aging and age-related diseases
TLDR
A combination of molecular, physiological and psychological modulatory approaches can be effective to prevent and/or treat various age-related diseases. Expand
Reversal of informational entropy and the acquisition of germ-like immortality by somatic cells.
TLDR
It is argued that persistent, structured information-sharing in both virtual and real domains, leads to increased biological complexity and functionality, which reflects upon human survival characteristics. Expand
Hormesis in aging
  • S. Rattan
  • Biology, Medicine
  • Ageing Research Reviews
  • 2008
TLDR
Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects that counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 185 REFERENCES
Physiology and pathophysiology of senescence.
  • K. Schmidt
  • Biology, Medicine
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1999
TLDR
A brief review is presented on the different hypotheses aiming at explaining the physiology and pathophysiology of ageing and senescence. Expand
[New horizons in medicine. Aging and the laws of modern physics].
  • G. Guarini
  • Computer Science, Medicine
  • Recenti progressi in medicina
  • 1994
TLDR
From the valuation of dynamic stability, dissipative structures and entropy, it appears possible in a near future to clarify many aspects of the nature and dynamics of aging. Expand
Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence.
TLDR
If further research supports this hypothesis, measures of complexity based on chaos theory and the related geometric concept of fractals may provide new ways to monitor senescence and test the efficacy of specific interventions to modify the age-related decline in adaptive capacity. Expand
Ageing and apoptosis
TLDR
There has been no direct evidence supporting the existence of such cross-communication between ageing and apoptosis in mammalian system, but research in this area is gaining momentum. Expand
Fractal dynamics in physiology: Alterations with disease and aging
TLDR
Application of fractal analysis may provide new approaches to assessing cardiac risk and forecasting sudden cardiac death, as well as to monitoring the aging process, and similar approaches show promise in assessing other regulatory systems, such as human gait control in health and disease. Expand
Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics
TLDR
The criteria of stability of far-from-equilibrium open systems and the theory of attractors help to sort the possible types of cellular stress responses: normal ageing, hormesis, stress-induced premature senescence, apoptosis or necrosis. Expand
A system approach modelling of the three-stage non-linear kinetics in biological ageing
TLDR
The classical concepts of lifespan, longevity and life expectancy are given new light using the model, which also gives clues to explain both the discrepancy in the age of death of individuals in a given population and the wide range of lifespans of species encountered in nature. Expand
On possible role of chaotic behavior of the gene regulation system in aging
TLDR
This approach allows to hypothesize that at least at the level of gene regulation aging can be a chaotic process (here implied that chaos is a kind of the complex systems dynamics controlled by strictly determined rules). Expand
Nonlinear Dynamics and Chaos Theory: Concepts and Applications Relevant to Pharmacodynamics
TLDR
Special attention is focused on three major fields of physiological systems with great importance in pharmacotherapy, namely cardiovascular, central nervous, and endocrine systems, where tools and concepts from nonlinear dynamics have been applied. Expand
[On possible role of chaotic behavior of the gene regulation system in aging].
  • M. Soloviev
  • Medicine
  • Advances in gerontology = Uspekhi gerontologii
  • 2001
TLDR
This approach allows to hypothesize that at least at the level of gene regulation aging can be a chaotic process (here implied that chaos is a kind of the complex systems dynamics controlled by strictly determined rules). Expand
...
1
2
3
4
5
...