• Corpus ID: 24010512

Practical application of genomics to the development of a topical cosmetic anti-aging regimen.

  title={Practical application of genomics to the development of a topical cosmetic anti-aging regimen.},
  author={Joseph R Kaczvinsky and Vince Bertucci and Juian-juian L. Fu},
  journal={Skin therapy letter},
  volume={16 7},
The development of topical cosmetic anti-aging products is becoming increasingly sophisticated. This is demonstrated by the benefit agents selected and the scientific approaches used to identify them, treatment protocols that increasingly incorporate multi-product regimens, and the level of rigor in the clinical testing used to demonstrate efficacy. Consistent with these principles, a new cosmetic anti-aging regimen was recently developed. The key product ingredients were identified based on an… 
2 Citations

Figures and Tables from this paper

Molecular mechanisms of action of topical antiaging compounds
The mechanisms behind effectiveness of the topical noninvasive antiaging compounds in use and also on the mechanism of action of potential topical antiaging substances under research are reported on.


Practical applications of genomics research for treatment of aging skin.
Skin aging integrates the impact of extrinsic skin insults (e.g., ultraviolet [UV] light, etc.) with chronological, genetically programmed decreases in cellular function. A genomic study of aged skin
Tretinoin cream 0.02% for the treatment of photodamaged facial skin: a review of 2 double-blind clinical studies.
Results indicate statistically significant improvement in fine wrinkled, coarse wrinkling, and yellowing with the use of tretinoin cream 0.02% at week-24 end point, compared with placebo.
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin 1
Niacinamide was well tolerated by the skin and provided significant improvements versus control in end points evaluated previously: fine lines/wrinkles, hyperpigmentation spots, texture, and red blotchiness.
Understanding metabolic pathways for skin anti-aging.
Using this in vitro biomarker approach, it is possible to detect skin barrier enhancement in response to the compounds niacinamide and hexamidine, matrix effects to the peptides Pal-KT and Pal-KTTKS, and hydration and matrix responses to niac inamide and N-acetylglucosamine.
Topical tretinoin in the treatment of aging skin.
Facilitating facial retinization through barrier improvement.
Results show that improving stratum corneum barrier function before beginning topical tretinoin therapy and continuing use of a barrier-enhancing cosmetic moisturizer during therapy facilitates the early phase of facial retinization and augments the treatment response.
Genomic-driven insights into changes in aging skin.
Analysis of gene expression differences between young and older sun-protected and sun-exposed skin showed that photoaging produces many similar (but more severe) changes in gene expression versus chronologic aging.
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin 1
Pal‐KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis.
Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.
Evidence is summarized that implicates a deficiency of superficial dermal collagen as the cause of the dermal aspects of photoaging and a mechanism through which UV radiation can lead to reduced collagen.
Modulation of gene expression induced in human epidermis by environmental stress in vivo.
The results suggest that MRP8 and MRP14 may be general, yet highly sensitive, markers for a great variety of skin stresses and that they are implicated in several epidermal repair pathways.