Practical Issues in the Management of Hypersensitivity Reactions: Sulfonamides

  title={Practical Issues in the Management of Hypersensitivity Reactions: Sulfonamides},
  author={Stephen A. Tilles},
  journal={Southern Medical Journal},
  • S. Tilles
  • Published 1 August 2001
  • Medicine, Biology
  • Southern Medical Journal
Approximately 3% of the general population and 60% of patients with human immunodeficiency virus (HIV) infection have adverse reactions when treated with sulfonamide antimicrobials. The most common clinical manifestations of sulfonamide hypersensitivity are fever and a maculopapular rash 7 to 14 days after initiating therapy, though a variety of more severe manifestations may occur. The sulfonamide chemical moiety is present in many medications that are not antimicrobials, and fortunately… 
Sulfonamide Allergies
For patients with an indication for a sulfonamide antimicrobial with a listed allergy, it is important for healthcare practitioners to adequately assess the allergic reaction to determine appropriate management and rechallenge and desensitization strategies may be appropriate for patients with delayed maculopapular eruptions.
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Clinical and laboratory markers of hypersensitivity to trimethoprim-sulfamethoxazole in patients with Pneumocystis carinii pneumonia and AIDS.
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Improved understanding of allergic drug reactions requires the following: better pharmacoepidemiologic studies, improved in vitro and in vivo methods of studying the immune responses involved, and expanded comparisons between the pharmacokinetics and pharmacodynamic effects of drugs and their metabolites.
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