Practical Issues in Imputation-Based Association Mapping

  title={Practical Issues in Imputation-Based Association Mapping},
  author={Yongtao Guan and Matthew Stephens},
  journal={PLoS Genetics},
  pages={851 - 861}
Imputation-based association methods provide a powerful framework for testing untyped variants for association with phenotypes and for combining results from multiple studies that use different genotyping platforms. Here, we consider several issues that arise when applying these methods in practice, including: (i) factors affecting imputation accuracy, including choice of reference panel; (ii) the effects of imputation accuracy on power to detect associations; (iii) the relative merits of… CONTINUE READING
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