PrP106-126 and Aβ1-42 Peptides Induce BV-2 Microglia Chemotaxis and Proliferation

@article{Tu2013PrP106126AA,
  title={PrP106-126 and Aβ1-42 Peptides Induce BV-2 Microglia Chemotaxis and Proliferation},
  author={Jian Tu and Lifeng Yang and Xiangmei Zhou and Kezong Qi and Jinguo Wang and Mohammed Kouadir and Lihua Xu and Xiaomin Yin and Deming Zhao},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={52},
  pages={107-116}
}
Transmissible spongiform encephalopathies (TSEs) and Alzheimer's disease (AD) belong to a growing family of neurodegenerative disorders that is characterized by the generation of toxic protein aggregates in affected brains (PrPSc and Aβ in TSEs and AD, respectively). To better understand how protein aggregates can modulate microglial processes in these diseases, we treated BV-2 microglia with PrP106-126 or Aβ1-42 peptides individually at three different concentrations (25–100 μM PrP106-12 and 2… CONTINUE READING

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