PrP in pathology and pathogenesis in scrapie-infected mice

@article{Bruce1994PrPIP,
  title={PrP in pathology and pathogenesis in scrapie-infected mice},
  author={Moira E. Bruce and Patricia A. McBride and M Haddad Jeffrey and Justin R Scott},
  journal={Molecular Neurobiology},
  year={1994},
  volume={8},
  pages={105-112}
}
PrP accumulation in the brains of mice infected with scrapie takes several different forms: amyloid plaques, widespread accumulation in neuropile, and perineuronal deposits. PrP is also sometimes detected within microglia and in or around astrocytes. There are dramatic and reproducible differences between scrapie strains in the relative prominence of these… CONTINUE READING