PrP genotypes of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease.

  title={PrP genotypes of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease.},
  author={Matteo Perucchini and Karen Griffin and Michael A Miller and Wilfred Goldmann},
  journal={The Journal of general virology},
  volume={89 Pt 5},
Variation in PrP prion gene sequence appears to modulate susceptibility to chronic wasting disease (CWD), a naturally occurring prion disease affecting four North American species of the family Cervidae. Wapiti (Cervus elaphus nelsoni) PrP is polymorphic at codon 132 [methionine (M) or leucine (L)]. We genotyped 171 samples, collected between 2002 and 2005 from CWD-infected and uninfected wapiti from three free-ranging populations in Colorado, USA, to study influences of PrP polymorphisms on… CONTINUE READING


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