PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice.

@article{Raeber1999PrPdependentAO,
  title={PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice.},
  author={Alex J. Raeber and Michael A. Klein and Rico Frigg and Eckhard Flechsig and Adriano Aguzzi and Charles Weissmann},
  journal={The EMBO journal},
  year={1999},
  volume={18 10},
  pages={2702-6}
}
An intact immune system, and particularly the presence of mature B lymphocytes, is crucial for mouse scrapie pathogenesis in the brain after peripheral exposure. Prions are accumulated in the lymphoreticular system (LRS), but the identity of the cells containing infectivity and their role in neuroinvasion have not been determined. We show here that although prion infectivity in the spleen is associated with B and T lymphocytes and to a lesser degree with the stroma, no infectivity could be… CONTINUE READING

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The role of the spleen in the neuroinvasion of scrapie in mice

C. A. Walker
Virus Res . • 1989
View 1 Excerpt
Highly Influenced

A crucial role for B cells in neuroinvasive scrapie.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine • 1999

Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication

T. ̈licke, M. Fischer, S. Brandner, A. Aguzzi, C. Weissmann
Proc . Natl Acad . Sci . USA • 1999

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