PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway.

@article{Zhang2011PrLZPP,
  title={PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway.},
  author={Dong Zhang and Dalin He and Yan Xue and Ruoxiang Wang and Kaijie Wu and Hongjun Xie and Jin Zeng and Xinyang Wang and Haiyen E. Zhau and Leland W. K. Chung and Luke Sien-Shih Chang and Lei Erbao Li},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={2193-202}
}
PrLZ/PC-1 is a newly identified, prostate-specific and androgen-inducible gene. Our previous study showed that PrLZ can enhance the proliferation and invasive capability of LNCaP cells, contributing to the development of prostate cancer. However, its potential role in androgen-independent processes remains elusive. In this study, we showed that PrLZ enhanced in vitro growth and colony formation of prostate cancer cells on androgen deprivation as well as tumorigenicity in castrated nude mice. In… CONTINUE READING

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